Structure of PDB 4nxr Chain A Binding Site BS01

Receptor Information
>4nxr Chain A (length=94) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GAMGKVTHSIHIEKSDTAADTYGFSLSSVEEDGIRRLYVNSVKETGLASK
KGLKAGDEILEINNRAADALNSSMMEDFFSQPSVGLLVRTYPEL
Ligand information
Receptor-Ligand Complex Structure
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PDB4nxr Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		T857 Y858 G859 F860 S861 L862 S863 S864 V865 E866 R871 N876 M911 F915
Binding residue
(residue number reindexed from 1)		T21 Y22 G23 F24 S25 L26 S27 S28 V29 E30 R35 N40 M75 F79
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction
GO:0090630 activation of GTPase activity

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Molecular Function
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Biological Process
External links
PDB RCSB:4nxr, PDBe:4nxr, PDBj:4nxr
PDBsum4nxr
PubMed27998539
UniProtQ13009|TIAM1_HUMAN Rho guanine nucleotide exchange factor TIAM1 (Gene Name=TIAM1)

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