Structure of PDB 4ntw Chain A Binding Site BS01

Receptor Information

>4ntw Chain A (length=410) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VVWALCFMGSLALLALVCTNRIQYYFLYPHVTKLDEVAATRLTFPAVTFC
NLNEFRFSRVTKNDLYHAGELLALLNNRYEIPDTQTADEKQLEILQDKAN
FRNFKPKPFNMLEFYDRAGHDIREMLLSCFFRGEQCSPEDFKVVFTRYGK
CYTFNAGQDGKPRLITMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEA
GIKVQIHSQDEPPLIDQLGFGVAPGFQTFVSCQEQRLIYLPPPWGDCKAT
TGEFYDTYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECAD
PALDFLVEKDNEYCVCEMPCNVTRYGKELSMVKIPSKASAKYLAKKYNKS
EQYIGENILVLDIFFEALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASI
LTVLELFDYA

Ligand information

Ligand ID

InChI

InChI=1S/Na/q+1

InChIKey

FKNQFGJONOIPTF-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Na+]

Formula

Name

SODIUM ION

PDB chain

4ntw Chain A Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4ntw X-ray structure of Acid-sensing ion channel 1-snake toxin complex reveals open state of a na(+)-selective channel.
Resolution	2.07 Å
Binding residue (original residue number in PDB)	T237 D238 T240
Binding residue (residue number reindexed from 1)	T193 D194 T196
Annotation score	5

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005272	sodium channel activity
GO:0015280	ligand-gated sodium channel activity

	Biological Process
GO:0006814	sodium ion transport

	Cellular Component
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:4ntw, PDBe:4ntw, PDBj:4ntw
PDBsum	4ntw
PubMed	24507937
UniProt	Q1XA76\|ASIC1_CHICK Acid-sensing ion channel 1 (Gene Name=ASIC1)

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