Structure of PDB 4nt6 Chain A Binding Site BS01

Receptor Information
>4nt6 Chain A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSHSMRYFYTAVSRPGRGEPRFIAVGYVDDTQFVQFDSDAASPRGEPRAP
WVEQEGPEYWDRETQKYKRQAQTDRVSLRNLRGYYNQSEAGSHTLQRMYG
CDLGPDGRLLRGYNQFAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAA
RTAEQLRAYLEGTCVEWLRRYLENGKKTLQRAEHPKTHVTHHPVSDHEAT
LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP
SGEEQRYTCHVQHEGLPEPLTLRW
Ligand information
>4nt6 Chain C (length=9) Species: 768716 (Influenza A virus (A/Boston/115JC/2009(H1N1))) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GILGFVFTL
Receptor-Ligand Complex Structure
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PDB4nt6 The immunodominant influenza A virus M158-66 cytotoxic T lymphocyte epitope exhibits degenerate class I major histocompatibility complex restriction in humans.
Resolution1.84 Å
Binding residue
(original residue number in PDB)
Y7 Y9 E63 K66 Y67 T73 V76 S77 N80 Y84 Y99 Y123 T143 K146 W147 Q155 L156 Y159 W167 Y171
Binding residue
(residue number reindexed from 1)
Y7 Y9 E63 K66 Y67 T73 V76 S77 N80 Y84 Y99 Y123 T143 K146 W147 Q155 L156 Y159 W167 Y171
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:4nt6, PDBe:4nt6, PDBj:4nt6
PDBsum4nt6
PubMed24990997
UniProtP10321|HLAC_HUMAN HLA class I histocompatibility antigen, C alpha chain (Gene Name=HLA-C)

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