Structure of PDB 4npm Chain A Binding Site BS01

Receptor Information
>4npm Chain A (length=210) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EYEERRDAEARRVKSGIKQASIFTLEECARIEAKIDEVVAKADKGLYREH
TVDRAPLRNKYFFGEGYTQERLYSKGEVDDIPDWVHELVIDRLVTHGVIP
EGFVNSAVINDYQPGGCIVSHVDPIHIFERPIVSVSFFSDSALCFGCKFL
FKPIRVSEPVLHLPVRRGSVTVLSGYAADDITHCIRPQDIKERRAVIILR
KTRADAPRLD
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4npm Chain A Residue 300 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4npm Crystal structure of the RNA demethylase ALKBH5 from zebrafish.
Resolution1.803 Å
Binding residue
(original residue number in PDB)		H135 D137 H197
Binding residue
(residue number reindexed from 1)		H121 D123 H183
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.53: mRNA N(6)-methyladenine demethylase.
Gene Ontology
Molecular Function
GO:0035515 oxidative RNA demethylase activity
Biological Process
GO:0006397 mRNA processing

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Molecular Function
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Biological Process
External links
PDB RCSB:4npm, PDBe:4npm, PDBj:4npm
PDBsum4npm
PubMed24561204
UniProtQ08BA6|ALKB5_DANRE RNA demethylase ALKBH5 (Gene Name=alkbh5)

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