Structure of PDB 4nnd Chain A Binding Site BS01

Receptor Information
>4nnd Chain A (length=283) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSARSFLERLEARAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRKN
RYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPH
TLLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQEPLQTGLFCIT
LIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAM
VEEARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLTMIPPDFSLF
DVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS
Ligand information
Receptor-Ligand Complex Structure
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PDB4nnd Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Resolution2.502 Å
Binding residue
(original residue number in PDB)		Y62 D64 D197 S229 S230 A231 C233 R235 Q276
Binding residue
(residue number reindexed from 1)		Y52 D54 D187 S219 S220 A221 C223 R225 Q265
Enzymatic activity
Catalytic site (original residue number in PDB) D197 S229 R235 T236 Q276
Catalytic site (residue number reindexed from 1) D187 S219 R225 T226 Q265
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0016311 dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4nnd, PDBe:4nnd, PDBj:4nnd
PDBsum4nnd
PubMed
UniProtQ99952|PTN18_HUMAN Tyrosine-protein phosphatase non-receptor type 18 (Gene Name=PTPN18)

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