Structure of PDB 4nm6 Chain A Binding Site BS01

Receptor Information
>4nm6 Chain A (length=407) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SCRCEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYTGKEGKS
SQGCPIAKWVVRRSSSEEKLLCLVRERAGHTCEAAVIVILILVWEGIPLS
LADKLYSELTETLRKYGTLTNRRCALNEERTCACQGLDPETCGASFSFGC
SWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLSTLMAPTYKK
LAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHAHRDLHNMQ
NGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVEAQEEKK
RSGAIQVLSSFRRKVRMLAEPVKTGSDEVWSDSEQSFLDPDIGGVAVAPT
HGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNEPKHGLALW
EAKMAEK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4nm6 Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation.
Resolution2.026 Å
Binding residue
(original residue number in PDB)		R1261 R1262 S1286 S1290 Y1294 K1299 S1303 D1384 Y1902 H1904
Binding residue
(residue number reindexed from 1)		R122 R123 S147 S151 Y155 K160 S164 D245 Y385 H387
Binding affinityPDBbind-CN: Kd=1.07uM
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Gene Ontology
Molecular Function
GO:0070579 5-methylcytosine dioxygenase activity
Biological Process
GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:4nm6, PDBe:4nm6, PDBj:4nm6
PDBsum4nm6
PubMed24315485
UniProtQ6N021|TET2_HUMAN Methylcytosine dioxygenase TET2 (Gene Name=TET2)

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