Structure of PDB 4njg Chain A Binding Site BS01
Receptor Information
>4njg Chain A (length=209) Species:
395019
(Burkholderia multivorans ATCC 17616) [
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TYAVKEIFYTLQGEGANAGRPAVFCRFAGCNLWSGREEDRAQAVCRFCDT
DFVGTDGENGGKFKDADALVATIAGLWPAGEAHRFVVCTGGEPMLQLDQP
LVDALHAAGFGIAIETNGSLPVLESIDWICVSPKADAPLVVTKGNELKVV
IPQDNQRLADYAKLDFEYFLVQPMDGPSRDLNTKLAIDWCKRHPQWRLSM
QTHKYLNIP
Ligand information
Ligand ID
SF4
InChI
InChI=1S/4Fe.4S
InChIKey
LJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
Software
SMILES
OpenEye OEToolkits 2.0.7
[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385
S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
Formula
Fe4 S4
Name
IRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain
4njg Chain A Residue 301 [
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Receptor-Ligand Complex Structure
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PDB
4njg
Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism.
Resolution
2.598 Å
Binding residue
(original residue number in PDB)
C31 W34 C46 C49 G92 N118 K135
Binding residue
(residue number reindexed from 1)
C30 W33 C45 C48 G91 N117 K134
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
F25 C31 C46 C49 D50 T51 E116 H204
Catalytic site (residue number reindexed from 1)
F24 C30 C45 C48 D49 T50 E115 H203
Enzyme Commision number
4.3.99.3
: 7-carboxy-7-deazaguanine synthase.
Gene Ontology
Molecular Function
GO:0000287
magnesium ion binding
GO:0003824
catalytic activity
GO:0016829
lyase activity
GO:0016840
carbon-nitrogen lyase activity
GO:0042802
identical protein binding
GO:0042803
protein homodimerization activity
GO:0046872
metal ion binding
GO:0051536
iron-sulfur cluster binding
GO:0051539
4 iron, 4 sulfur cluster binding
GO:1904047
S-adenosyl-L-methionine binding
Biological Process
GO:0008616
queuosine biosynthetic process
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:4njg
,
PDBe:4njg
,
PDBj:4njg
PDBsum
4njg
PubMed
24362703
UniProt
A0A0H3KB22
|QUEE_BURM1 7-carboxy-7-deazaguanine synthase (Gene Name=queE)
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