Structure of PDB 4nh6 Chain A Binding Site BS01

Receptor Information
>4nh6 Chain A (length=272) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIP
HFPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEAYC
VLPLNVVTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAV
IIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLT
NLNQPLLDVDHTSSRLNLLTPRHSSAEKRKAKWESLQNKQILVPELCAIH
PIPASLWRKAVCLPSILYRLHC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4nh6 A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
Resolution2.551 Å
Binding residue
(original residue number in PDB)		Y926 R927 F950 S952 Y961 Y962 K965 Y966 S1005 W1013 L1016 Q1017 Q1020 I1021
Binding residue
(residue number reindexed from 1)		Y155 R156 F179 S181 Y190 Y191 K194 Y195 S225 W233 L236 Q237 Q240 I241
Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4nh6, PDBe:4nh6, PDBj:4nh6
PDBsum4nh6
PubMed24486018
UniProtQ9UPY3|DICER_HUMAN Endoribonuclease Dicer (Gene Name=DICER1)

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