Structure of PDB 4nh5 Chain A Binding Site BS01

Receptor Information
>4nh5 Chain A (length=271) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPH
FPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEKYCV
LPLNVVNSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDA
VIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDL
TNLNQPLLDVDHTSSRLNLLTPRHAEKRKAKWESLQNKQILVPELCAIHP
IPASLWRKAVCLPSILYRLHC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4nh5 A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
Resolution2.55 Å
Binding residue
(original residue number in PDB)		Y926 R927 F950 Y961 Y962 K965 Y966 W1014 L1017 Q1018 Q1021 I1022
Binding residue
(residue number reindexed from 1)		Y156 R157 F180 Y191 Y192 K195 Y196 W232 L235 Q236 Q239 I240
Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4nh5, PDBe:4nh5, PDBj:4nh5
PDBsum4nh5
PubMed24486018
UniProtQ9UPY3|DICER_HUMAN Endoribonuclease Dicer (Gene Name=DICER1)

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