Structure of PDB 4nh3 Chain A Binding Site BS01

Receptor Information
>4nh3 Chain A (length=268) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPH
FPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLYCVLP
LNVVTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDAVIIP
RYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLN
QPLLDVDHTSSRLNLLTPLSSAEKRKAKWESLQNKQILVPELCAIHPIPA
SLWRKAVCLPSILYRLHC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4nh3 A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
Resolution2.616 Å
Binding residue
(original residue number in PDB)		Y926 R927 F950 P951 S952 Y961 Y962 K965 Y966 S1005 S1006 W1014 L1017 Q1018 Q1021 I1022
Binding residue
(residue number reindexed from 1)		Y152 R153 F176 P177 S178 Y187 Y188 K191 Y192 S220 S221 W229 L232 Q233 Q236 I237
Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4nh3, PDBe:4nh3, PDBj:4nh3
PDBsum4nh3
PubMed24486018
UniProtQ9UPY3|DICER_HUMAN Endoribonuclease Dicer (Gene Name=DICER1)

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