Structure of PDB 4ngg Chain A Binding Site BS01

Receptor Information
>4ngg Chain A (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPH
FPVYTRSGEVTISIELAASGFMLSLQMLELITRLHQYIFSHILRLEYCVL
PLNVVNDSTLDIDFKFMEDIEKSEARIGIPSTKYTKETPFVFKLEDYQDA
VIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDL
TNLNQPLLDVDHTSSRLNLLTPRRKAKWESLQNKQILVPELCAIHPIPAS
LWRKAVCLPSILYRLHC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ngg A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer.
Resolution2.6 Å
Binding residue
(original residue number in PDB)
Y926 R927 F950 S952 Y961 Y962 Y966 W1014 Q1021 I1022
Binding residue
(residue number reindexed from 1)
Y156 R157 F180 S182 Y191 Y192 Y196 W228 Q235 I236
Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Gene Ontology

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Molecular Function
External links
PDB RCSB:4ngg, PDBe:4ngg, PDBj:4ngg
PDBsum4ngg
PubMed24486018
UniProtQ9UPY3|DICER_HUMAN Endoribonuclease Dicer (Gene Name=DICER1)

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