Structure of PDB 4nge Chain A Binding Site BS01

Receptor Information
>4nge Chain A (length=985) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AAACERALQYKLGDKIHGFTVNQVTSVPELFLTAVKLTHDDTGARYLHLA
REDTNNLFSVQFRTTPMDSTGVPHILQHTVLCGSQKYPCRDPFFKMLNRS
LSTFMNAFTASDYTLYPFSTQNPKDFQNLLSVYLDATFFPCLRELDFWQE
GWRLEHENPSDPQTPLVFKGVVFNEMKGAFTDNERIFSQHLQNRLLPDHT
YSVVSGGDPLCIPELTWEQLKQFHATHYHPSNARFFTYGNFPLEQHLKQI
HEEALSKFQKIEPSTVVPAQTPWDKPREFQITCGPDSFATPSKQTTVSVS
FLLPDITDTFEAFTLSLLSSLLTSGPNSPFYKALIESGLGTDFSPDVGYN
GYTREAYFSVGLQGIVEKDIETVRSLIDRTIDEVVEKGFEDDRIEALLHK
IEIQMKHQSTSFGLMLTSYIASCWNHDGDPVELLKLGNQLAKFRQCLQEN
PKFLQEKVKQYFKNNQHKLTLSMRPDDKYHEKQAQVEATKLKQKVEALSP
GDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAG
DIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLD
YREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMM
QLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLT
PAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCS
VNATPQQMPQTEKAVEDFLRSIGRSPVRPHTVEKPVIRKLVMEPTFKPWQ
MKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREK
GGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDI
DEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLL
AVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIR
Ligand information
Receptor-Ligand Complex Structure
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PDB4nge Molecular basis of substrate recognition and degradation by human presequence protease.
Resolution2.704 Å
Binding residue
(original residue number in PDB)		Q107 H108 F123 F124 L127 S130 S132 T133 F134 M135 N136 A137 F138 T139 E205 R215 G236 R900 Y906 S961
Binding residue
(residue number reindexed from 1)		Q77 H78 F93 F94 L97 S100 S102 T103 F104 M105 N106 A107 F108 T109 E175 R185 G206 R848 Y854 S909
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008047 enzyme activator activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006626 protein targeting to mitochondrion
GO:0016485 protein processing
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4nge, PDBe:4nge, PDBj:4nge
PDBsum4nge
PubMed24931469
UniProtQ5JRX3|PREP_HUMAN Presequence protease, mitochondrial (Gene Name=PITRM1)

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