Structure of PDB 4ndi Chain A Binding Site BS01

Receptor Information
>4ndi Chain A (length=180) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPQARYHWLVLPWTSI
SSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVH
LHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMP
ELLKLPLRCHECQQLLPSIPQLKEHLRKHW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ndi Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		W167 Y195 S255 K277 H278
Binding residue
(residue number reindexed from 1)		W7 Y35 S95 K117 H118
Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:4ndi, PDBe:4ndi, PDBj:4ndi
PDBsum4ndi
PubMed24362567
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

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