Structure of PDB 4ndh Chain A Binding Site BS01

Receptor Information
>4ndh Chain A (length=180) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMGHWSQGLKISMQDPKMQVYKDEQVVVIKDKYPKARYHWLVLPWTSI
SSLKAVAREHLELLKHMHTVGEKVIVDFAGSSKLRFRLGYHAIPSMSHVH
LHVISQDFDSPCLKNKKHWNSFNTEYFLESQAVIEMVQEAGRVTVRDGMP
ELLKLPLRCHECQQLLPSIPQLKEHLRKHW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ndh Aprataxin resolves adenylated RNA-DNA junctions to maintain genome integrity.
Resolution1.848 Å
Binding residue
(original residue number in PDB)		W167 Y195 K197 S255 M256 K277 H278
Binding residue
(residue number reindexed from 1)		W7 Y35 K37 S95 M96 K117 H118
Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:4ndh, PDBe:4ndh, PDBj:4ndh
PDBsum4ndh
PubMed24362567
UniProtQ7Z2E3|APTX_HUMAN Aprataxin (Gene Name=APTX)

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