Structure of PDB 4nca Chain A Binding Site BS01 |
| >4nca Chain A (length=683) Species: 274 (Thermus thermophilus)
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HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARR
AGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD
PGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAV
LDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTW
ELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKDPRK
PIPHLTGLLVPVLTLEDLHEEEGSLALSLPWEERRRRTREIASWIGRRLG
LGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLD
GAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEG
VQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALL
GLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLL
WTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQD
EFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFL
LLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRL
PAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV |
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| PDB | 4nca Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. |
| Resolution | 2.489 Å |
Binding residue
(original residue number in PDB) | Y43 A170 Y171 R172 I173 R192 T201 V264 L265 L279 S280 L281 R286 M413 W415 R418 K422 Q433 I434 N436 R446 N449 K457 E512 R513 P550 R580 R611 G612 T613 P614 R615 A644 S645 A648 P650 R651 H657 R661 V685 |
Binding residue
(residue number reindexed from 1) | Y41 A168 Y169 R170 I171 R190 T199 V262 L263 L277 S278 L279 R284 M411 W413 R416 K420 Q431 I432 N434 R444 N447 K455 E510 R511 P548 R578 R609 G610 T611 P612 R613 A642 S643 A646 P648 R649 H655 R659 V683 |
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