Structure of PDB 4n78 Chain A Binding Site BS01

Receptor Information
>4n78 Chain A (length=1184) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VTLEDALSNVDLLEELPLGIARYIEQATVHSSMNEMLEEGQEYAVMLYTW
RSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERF
CGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHS
AYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEE
LLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDA
KKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCTS
SGSSPQYNICEQMIQIREDHMRFISELARYSAQKTDAEYRKLFDLALQGL
QLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDSAEEYERATRYNYTSEEK
FALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQ
AIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPFDIKVPRRA
VGPSSTQLYMVRTMLESLIAKTLRSSLEGPTILDIEKFHRESFFYTHLIN
FSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKE
ASMMEYVLYSLDLYNDSAHYALTRFNKQFLYDEIEAEVNLCFDQFVYKLA
DQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQL
LGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSIVELDGLLEINRM
THKLLSRYLTLDGFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCY
NGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRN
FVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMP
KICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAILFC
LLIEQSLSLEEVCDLLHAAPFQNILPRVHVKEGERLDAKMKRLESKYAPL
HLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSFLDDP
IWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGL
HWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVER
IRKFQILNDEIITILDKYLKEHVRCFQPPIHQSL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4n78 The WAVE Regulatory Complex Links Diverse Receptors to the Actin Cytoskeleton.
Resolution2.43 Å
Binding residue
(original residue number in PDB)		L1080 E1084 R1085 L1086
Binding residue
(residue number reindexed from 1)		L1023 E1027 R1028 L1029
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000340 RNA 7-methylguanosine cap binding
GO:0003779 actin binding
GO:0005515 protein binding
GO:0030371 translation repressor activity
GO:0031267 small GTPase binding
GO:0051015 actin filament binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006417 regulation of translation
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0008360 regulation of cell shape
GO:0010592 positive regulation of lamellipodium assembly
GO:0016601 Rac protein signal transduction
GO:0017148 negative regulation of translation
GO:0030032 lamellipodium assembly
GO:0030154 cell differentiation
GO:0030833 regulation of actin filament polymerization
GO:0031175 neuron projection development
GO:0031529 ruffle organization
GO:0031641 regulation of myelination
GO:0032869 cellular response to insulin stimulus
GO:0045773 positive regulation of axon extension
GO:0048675 axon extension
GO:0050772 positive regulation of axonogenesis
GO:0050890 cognition
GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway
GO:0051602 response to electrical stimulus
GO:0097484 dendrite extension
GO:0099563 modification of synaptic structure
GO:0099578 regulation of translation at postsynapse, modulating synaptic transmission
GO:1900006 positive regulation of dendrite development
GO:1900029 positive regulation of ruffle assembly
GO:1903422 negative regulation of synaptic vesicle recycling
GO:1905274 regulation of modification of postsynaptic actin cytoskeleton
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation
Cellular Component
GO:0001726 ruffle
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0030027 lamellipodium
GO:0031209 SCAR complex
GO:0031252 cell leading edge
GO:0032433 filopodium tip
GO:0034774 secretory granule lumen
GO:0035580 specific granule lumen
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0044294 dendritic growth cone
GO:0044295 axonal growth cone
GO:0045202 synapse
GO:0048471 perinuclear region of cytoplasm
GO:0060076 excitatory synapse
GO:0070062 extracellular exosome
GO:0090724 central region of growth cone
GO:0090725 peripheral region of growth cone
GO:0098794 postsynapse
GO:1904724 tertiary granule lumen

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4n78, PDBe:4n78, PDBj:4n78
PDBsum4n78
PubMed24439376
UniProtQ7L576|CYFP1_HUMAN Cytoplasmic FMR1-interacting protein 1 (Gene Name=CYFIP1)

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