Structure of PDB 4n76 Chain A Binding Site BS01

Receptor Information
>4n76 Chain A (length=641) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARR
AGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKD
PGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGAV
LDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNALPGGLS
LLDYHASKGRLQGREGGHLTGLLVPVLTLEDSLALSLPWEERRRRTREIA
SWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQET
ALALLRLDGAQGWPEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREA
LRKAKEEGVQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEER
HRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAV
GGDGGHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLL
RDGRVPQDEFALALEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYV
PLEDKTFLLLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPA
SGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4n76 Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Resolution2.89 Å
Binding residue
(original residue number in PDB)		A170 R172 I173 L279 L281 R286 M413 W415 K422 Q433 I434 N436 H445 R446 N449 K457 R580 R611 T613 P614 R615 P650 R651 H657 R661 V685
Binding residue
(residue number reindexed from 1)		A168 R170 I171 L235 L237 R242 M369 W371 K378 Q389 I390 N392 H401 R402 N405 K413 R536 R567 T569 P570 R571 P606 R607 H613 R617 V641
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:4n76, PDBe:4n76, PDBj:4n76
PDBsum4n76
PubMed24374628
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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