Structure of PDB 4n5z Chain A Binding Site BS01

Receptor Information

>4n5z Chain A (length=324) Species: 284218 (Influenza A virus (A/Viet Nam/1203/2004(H5N1)))

DPGDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKKHNGKLCDLDGV
KPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFND
YEELKHLLSRINHFEKIQIIPKSSWSSHEASLGVSSACPYQGKSSFFRNV
VWLIKKDSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNPTTY
ISVGTSTLNQRLVPRIATRSKVKGLSGRMEFFWTILKPNDAINFESNGNF
IAPEYAYKIVKKGDSTIMKSELEYGNCNTKCQTPMGAINSSMPFHNIHPL
TIGECPKYVKSNRLVLAIGLRNSP

Ligand information

• Ligand ID: BMA
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6-/m1/s1
• InChIKey: WQZGKKKJIJFFOK-RWOPYEJCSA-N
• SMILES:
  CACTVS 3.341: OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@@H]([C@@H](O1)O)O)O)O)O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: beta-D-mannopyranose;
  beta-D-mannose;
  D-mannose;
  mannose
• ZINC: ZINC000003830679
• PDB chain: 4n5z Chain n Residue 3

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4n5z Hemagglutinin Receptor Specificity and Structural Analyses of Respiratory Droplet-Transmissible H5N1 Viruses.
• Resolution: 2.9537 Å
• Binding residue (original residue number in PDB): S137 K224 G225
• Binding residue (residue number reindexed from 1): S136 K223 G224
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0046789 host cell surface receptor binding

Biological Process

• GO:0019064 fusion of virus membrane with host plasma membrane

Cellular Component

• GO:0019031 viral envelope

External links

• PDB: RCSB:4n5z, PDBe:4n5z, PDBj:4n5z
• PDBsum: 4n5z
• PubMed: 24173215
• UniProt: Q5EP31