Structure of PDB 4n56 Chain A Binding Site BS01

Receptor Information
>4n56 Chain A (length=494) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEEAPWPPPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALR
DLKEARGLLAKDLSVLALREGLGLPPGDDPMLLAYLLDPSNTTPEGVARR
YGGEWTEEAGERAALSERLFANLWGRLEGEERLLWLYREVERPLSAVLAH
MEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGHPFNLNSRDQLERV
LFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTKLKS
TYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQR
IRRAFIAEEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETA
AKTINFGVLYGFPKVRAWLEKTLEEGRRRGYVETLFGRRRYVPDLEARVK
SVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARMLLQVHDELV
LEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
Ligand information
Receptor-Ligand Complex Structure
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PDB4n56 A Conservative Isoleucine to Leucine Mutation Causes Major Rearrangements and Cold Sensitivity in KlenTaq1 DNA Polymerase.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		R487 T506 K508 T509 S513 T514 S515 A516 R536 K540 Y545 R573 N583 I584 P585 V586 R587 H784
Binding residue
(residue number reindexed from 1)		R194 T213 K215 T216 S220 T221 S222 A223 R243 K247 Y252 R280 N290 I291 P292 V293 R294 H446
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0001882 nucleoside binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4n56, PDBe:4n56, PDBj:4n56
PDBsum4n56
PubMed25537790
UniProtP19821|DPO1_THEAQ DNA polymerase I, thermostable (Gene Name=polA)

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