Structure of PDB 4n48 Chain A Binding Site BS01

Receptor Information
>4n48 Chain A (length=401) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKRKMIIEDETEF
CGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYEMIRGVFFLNRAAMKM
ANMDFVFDRMFTNPRDSYGKPLVKDRELLYFADVCAGPGGFSEYVLWRKK
WHAKGFGMTLKGPNDFKLEDFSELFEPYYGEGGIDGDGDITRPENISAFR
NFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLCQFLMALSIVR
TGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVVC
KGLKVGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYM
IRSNESHCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQAR
V
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4n48 Structural analysis of human 2'-O-ribose methyltransferases involved in mRNA cap structure formation.
Resolution2.704 Å
Binding residue
(original residue number in PDB)		N234 R235 K239 F367 S368 K404
Binding residue
(residue number reindexed from 1)		N94 R95 K99 F221 S222 K258
Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4n48, PDBe:4n48, PDBj:4n48
PDBsum4n48
PubMed24402442
UniProtQ8N1G2|CMTR1_HUMAN Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (Gene Name=CMTR1)

[Back to BioLiP]