Structure of PDB 4n0t Chain A Binding Site BS01

Receptor Information
>4n0t Chain A (length=363) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RNRELTTVLVKNLPKSYNQNKVYKYFKHCGPIIHVDVADSLKKNFRFARI
EFARYDGALAAITKTHKVVGQNEIIVSHLTECTLWMTNFPPSYTQRNIRD
LLQDINVVALSIRLPSLRFNTSRRFAYIDVTSKEDARYCVEKLNGLKIEG
YTLVTKVSNPLEKSKRTDSATLEGREIMIRNLSTELLDENLLRESFEGFG
SIEKINIPAGQKEHSFNNCCAFMVFENKDSAERALQMNRSLLGNREISVS
LADKKPFLERNEVKRLLASRNSKELETLICLFPLSDKVSPSLICQFLQEE
IHINEKDIRKILLVSDFNGAIIIFRDSKFAAKMLMILNGSQFQGKVIRSG
TINDMKRYYNNQQ
Ligand information
>4n0t Chain B (length=65) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggucaauuugaaacaauacagagaugaucagcgguuccccuggaugaacc
guuuuacaaagagac
.<<<..<<<<...................<<<<<<<<.<<.>>..>>>>>
>>>...>>>>..>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4n0t Core structure of the U6 small nuclear ribonucleoprotein at 1.7- angstrom resolution.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		R36 R38 W120 T122 N123 R148 P150 S151 R153 F154 S157 R158 R159 F160 Y162 S193 N194 P195 K198 R201 T202 D203 E211 M213 R215 N216 K239 N241 P243 Q246 F251 N252 N253 C255 F257 R274 S283 D288 K289 K290 P291 F292 L293 R295 N296 K299 D351 N395
Binding residue
(residue number reindexed from 1)		R1 R3 W85 T87 N88 R113 P115 S116 R118 F119 S122 R123 R124 F125 Y127 S158 N159 P160 K163 R166 T167 D168 E176 M178 R180 N181 K204 N206 P208 Q211 F216 N217 N218 C220 F222 R239 S248 D253 K254 K255 P256 F257 L258 R260 N261 K264 D316 N360
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:4n0t, PDBe:4n0t, PDBj:4n0t
PDBsum4n0t
PubMed24837192
UniProtP49960|PRP24_YEAST U4/U6 snRNA-associated-splicing factor PRP24 (Gene Name=PRP24)

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