Structure of PDB 4n0o Chain A Binding Site BS01

Receptor Information
>4n0o Chain A (length=395) Species: 299386 (Equine arteritis virus Bucyrus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSAVCTVCGAAPVAKSACGGWFCGNCVPYHAGHCHTTSLFACGHDIMYRS
TYCTMCEGSQMVPKVPHPILDHLLCHIDYGSKEETLVVADRTTSPPGRYK
VGHKVVAVDVGGNIVFGCGPGSHIAVPLQDTLKGVVVNKALKNAAASEYV
EGPPGSGKTFHLVKDVLAVVGSATLVVPTHASMLDCINKLKQAGADPYFV
VPKYTVLDFPRPGSGNITVRLPQVGTSEGETFVDEVAYFSPVDLARILTQ
GRVKGYGDLNQLGCVGPASVPRNLWLRHFVSLEPLRVCHRFGAAVCDLIK
GIYPYYEPAPHTTKVVFVPNPDFEKGVVITAYHKDRGLGHRTIDSIQGCT
FPVVTLRLPTPQSLTRPRAVVAVTRASQELYIYDPFDQLSGLLKF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4n0o Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		Y81 R102 H186 Q229 Y244 C270 V271 Y338 H339 T348 D350 R374
Binding residue
(residue number reindexed from 1)		Y79 R98 H180 Q223 Y238 C264 V265 Y332 H333 T342 D344 R368
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.21.-
3.4.22.-
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:4n0o, PDBe:4n0o, PDBj:4n0o
PDBsum4n0o
PubMed24369429
UniProtP19811|RPOA_EAVBU Replicase polyprotein 1ab (Gene Name=rep)

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