Structure of PDB 4myk Chain A Binding Site BS01

Receptor Information

>4myk Chain A (length=288) Species: 5693 (Trypanosoma cruzi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TDDPRLLSLFSAQREEDADIVIIGFPYDEGCVRNGGRAGAKKGPAAFRFF
LQRLGSVNNLELNVDASHLKLYDAGDITASTLEEAHEKLESKVFTVLARG
AFPFVIGGGNDQSAPNGRAMLRAFPGDVGVINVDSHLDVRGTPFRQLLEE
SSFSGKRFVEFACQGSQCGALHAQYVRDHQGHLMWLSEVRKKGAVAALED
AFGLTGKNTFFSFDVDSLKSSDMPGVSCPAAVGLSAQEAFDMCFLAGKTP
TVMMMDMSELNPLVEEYRSPRVAVYMFYHFVLGFATRP

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

4myk Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	4myk Formiminoglutamase from trypanosoma cruzi is an arginase-like manganese metalloenzyme.
Resolution	1.518 Å
Binding residue (original residue number in PDB)	N114 D138 D228
Binding residue (residue number reindexed from 1)	N110 D134 D214
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	N114 D138 H140 D142 D228 D230 E273
Catalytic site (residue number reindexed from 1)	N110 D134 H136 D138 D214 D216 E259
Enzyme Commision number	3.5.3.8: formimidoylglutamase.

Gene Ontology

	Molecular Function
GO:0008783	agmatinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0033389	putrescine biosynthetic process from arginine, using agmatinase

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4myk, PDBe:4myk, PDBj:4myk
PDBsum	4myk
PubMed	24261485
UniProt	Q4DSA0

[Back to BioLiP]