Structure of PDB 4mvi Chain A Binding Site BS01

Receptor Information

>4mvi Chain A (length=172) Species: 9606 (Homo sapiens)

DLIPAPPLSKVPLQQNFQDNQFHGKWYVVGVAGNKSLREDKDPWKMYATI
YELKEDKSYNVTSVGFGTKKCHYKIRTFVPGSQPGEFTLGRIKSRPGRTS
ALVRVVSTNYNQHAMVFFKVVQQNRESFNITLYGRTKELTSELKENFIRF
SKSLGLPENHIVFPVPIDQCID

Ligand information

>4mvi Chain B (length=13) Species: 9606 (Homo sapiens)

KLVFFAEDVGSNK

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4mvi High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer beta-amyloid peptide.
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): W49 K50 Y52 T54 S68 V69 G70 H77 K79 R81 T104 F123 V125 Q127 N134 T136 Y138 P169
• Binding residue (residue number reindexed from 1): W44 K45 Y47 T49 S63 V64 G65 H72 K74 R76 T99 F118 V120 Q122 N129 T131 Y133 P164

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0005515 protein binding
• GO:0036094 small molecule binding
• GO:0042802 identical protein binding
• GO:0140315 iron ion sequestering activity
• GO:1903981 enterobactin binding

Biological Process

• GO:0006826 iron ion transport
• GO:0006915 apoptotic process
• GO:0015891 siderophore transport
• GO:0042742 defense response to bacterium
• GO:0045087 innate immune response
• GO:0120162 positive regulation of cold-induced thermogenesis

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0031410 cytoplasmic vesicle
• GO:0035580 specific granule lumen
• GO:0060205 cytoplasmic vesicle lumen
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:4mvi, PDBe:4mvi, PDBj:4mvi
• PDBsum: 4mvi
• PubMed: 27029347
• UniProt: P80188|NGAL_HUMAN Neutrophil gelatinase-associated lipocalin (Gene Name=LCN2)