Structure of PDB 4mth Chain A Binding Site BS01

Receptor Information
>4mth Chain A (length=139) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIRCPKGSKAYGSHCYALFLSPKSWTDADLACQKRPSGNLVSVLSGAEGS
FVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGWEWSSSDVMNYFAWERN
PSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4mth Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4mth Antibacterial membrane attack by a pore-forming intestinal C-type lectin.
Resolution1.47 Å
Binding residue
(original residue number in PDB)		H107 E121
Binding residue
(residue number reindexed from 1)		H71 E85
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0038023 signaling receptor activity
GO:0042802 identical protein binding
GO:0042834 peptidoglycan binding
GO:0070492 oligosaccharide binding
Biological Process
GO:0006953 acute-phase response
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007165 signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0009609 response to symbiotic bacterium
GO:0009611 response to wounding
GO:0010838 positive regulation of keratinocyte proliferation
GO:0043434 response to peptide hormone
GO:0045617 negative regulation of keratinocyte differentiation
GO:0050728 negative regulation of inflammatory response
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0090303 positive regulation of wound healing
GO:0106015 negative regulation of inflammatory response to wounding
GO:2000972 positive regulation of detection of glucose
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4mth, PDBe:4mth, PDBj:4mth
PDBsum4mth
PubMed24256734
UniProtQ06141|REG3A_HUMAN Regenerating islet-derived protein 3-alpha (Gene Name=REG3A)

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