Structure of PDB 4msx Chain A Binding Site BS01

Receptor Information
>4msx Chain A (length=395) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YAYLETVVREKLDFDSEKICCITLSPLNVYCCLVCGHYYQGRHEKSPAFI
HSIDENHHVFLNLTSLKFYMLPQNVQILHDGEVQLLNSIKFAAYPTYCPK
DLEDFPRQCFDLSNRTYLNGFIGFTNAATYDYAHSVLLLISHMVPVRDHF
LLNHFDNQGEFIKRLSICVKKIWSPKLFKHHLSVDDFVSYLKVREGLNLN
PIDPRLFLLWLFNKICSSSNDLKSILNHSCKGKVKIAKSESVTGKVIVKP
FWVLTLDLPEFSPFEDGNSVDDLPQINITKLLTKFTKTVFELTRLPQFLI
FHFNRFDRNSDHPVKNRNQTLVEFSSELEILHVKYRLKANVVHVVIGDEK
SHWITQLYDNKSEKWIEIDGINTTEREAELLFLKETFIQVWEKQE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4msx Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4msx The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing.
Resolution1.87 Å
Binding residue
(original residue number in PDB)		C60 C63 H79 H85
Binding residue
(residue number reindexed from 1)		C32 C35 H51 H57
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0016579 protein deubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0046540 U4/U6 x U5 tri-snRNP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4msx, PDBe:4msx, PDBj:4msx
PDBsum4msx
PubMed24681967
UniProtP43589|SAD1_YEAST Pre-mRNA-splicing factor SAD1 (Gene Name=SAD1)

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