Structure of PDB 4mdi Chain A Binding Site BS01

Receptor Information
>4mdi Chain A (length=179) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFA
SFEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREP
NVLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLP
FLPSTEDVYDCRVEHWGLDEPLLKHWEFD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4mdi A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Q9 E11 A52 S53 F54 N62 V65 N69 I72
Binding residue
(residue number reindexed from 1)		Q7 E9 A50 S51 F52 N60 V63 N67 I70
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4mdi, PDBe:4mdi, PDBj:4mdi
PDBsum4mdi
PubMed24190431
UniProtP01903|DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain (Gene Name=HLA-DRA)

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