Structure of PDB 4mdd Chain A Binding Site BS01
Receptor Information
>4mdd Chain A (length=247) Species:
9606
(Homo sapiens) [
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PTLVSALETIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAK
AIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSSANLLCFAPDLII
NEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDG
LKSQALFDAIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMHEVV
ENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
Ligand information
>4mdd Chain C (length=13) Species:
9606
(Homo sapiens) [
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LGLEDIIRKALMG
Receptor-Ligand Complex Structure
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PDB
4mdd
Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12
Resolution
2.4 Å
Binding residue
(original residue number in PDB)
V571 V575 K579 L589 M593 W600 N759
Binding residue
(residue number reindexed from 1)
V42 V46 K50 L60 M64 W71 N230
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:4mdd
,
PDBe:4mdd
,
PDBj:4mdd
PDBsum
4mdd
PubMed
UniProt
P04150
|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)
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