Structure of PDB 4m38 Chain A Binding Site BS01

Receptor Information

>4m38 Chain A (length=334) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DAFVNRIDRNIPVPARLRHTPVSLIEAVNDFHYAMMNDEERNNFYYEVLK
KHVTPETGVLEIGAGSGLLSLMAAKLGAKWVVAVEGSEELAKLARENIRA
NNMEHQVKVLHMMSTELKSKHLPEPPDVLLSEIFGTMMLGESALDYVVDV
RNRLLKPTTKIIPQFGTQYAVPIECDALHRISSVSGWRDLDLKHMMTLQD
TVSIVFAKHYGIRMNSVNFRRLSDPIELFRVDFSSSNRNDIPRRKHFDVV
AKESGTAHAMLFYWKVTDDEFVMSTDPEDTVNNFPRDMQWGQALQLLDAS
NGPLPTPVVFTEGKNYNFECNFSGDRVILHMQLC

Ligand information

>4m38 Chain E (length=4) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

SGRG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4m38 Structural determinants for the strict monomethylation activity by trypanosoma brucei protein arginine methyltransferase 7.
Resolution	2.2 Å
Binding residue (original residue number in PDB)	D70 F71 M75 E172 F174 G175 T176 E181 F246 K248 H249 Q329 W330
Binding residue (residue number reindexed from 1)	D30 F31 M35 E132 F134 G135 T136 E141 F206 K208 H209 Q289 W290

Enzymatic activity

Enzyme Commision number

2.1.1.-

Gene Ontology

	Molecular Function
GO:0016274	protein-arginine N-methyltransferase activity

	Biological Process
GO:0018216	peptidyl-arginine methylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:4m38, PDBe:4m38, PDBj:4m38
PDBsum	4m38
PubMed	24726341
UniProt	Q582G4\|ANM7_TRYB2 Protein arginine N-methyltransferase 7 (Gene Name=PRMT7)

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