Structure of PDB 4m1z Chain A Binding Site BS01

Receptor Information

>4m1z Chain A (length=317) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

DRPWANDYLRIQEAQKFATGAGVTVAVIDTGVNGSPRVPAEPGGDFVDAA
GNGMSDCDAHGTMTAAIIGGRPSPTDGFVGMAPDVRLLSLRQTSVAGSIR
SLARSVVHAANLGAQVINISEAACYKVTRRIDETSLGAAINYAVNVKGAV
IVVAAGNTGQDCSQNPPPDPSVPSDPRGWREVQTIVSPAWYDPLVLTVGS
IGQNGQPSNFSMSGPWVGAAAPGENLTSLGYDGQPVNATPGEDGPVPLNG
TSFSAAYVSGLAALVKQRFPDLTPAQIINRITATARHPGGGVDNYVGAGV
IDPVAALTWEIPDGPEK

Ligand information

>4m1z Chain C (length=10) Species: 246196 (Mycolicibacterium smegmatis MC2 155)

EVPPPVYIPP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4m1z The putative propeptide of MycP1 in mycobacterial type VII secretion system does not inhibit protease activity but improves protein stability.
• Resolution: 2.25 Å
• Binding residue (original residue number in PDB): C120 D121 A122 M126 Y313 P317 V318 N319 A320 P322 P327
• Binding residue (residue number reindexed from 1): C57 D58 A59 M63 Y231 P235 V236 N237 A238 P240 P245

Enzymatic activity

• Catalytic site (original residue number in PDB): D92 H123 N239 S334
• Catalytic site (residue number reindexed from 1): D29 H60 N157 S252
• Enzyme Commision number: 3.4.21.-

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:4m1z, PDBe:4m1z, PDBj:4m1z
• PDBsum: 4m1z
• PubMed: 24248472
• UniProt: A0QNL1|MYCP1_MYCS2 Mycosin-1 (Gene Name=mycP1)