Structure of PDB 4lyi Chain A Binding Site BS01

Receptor Information

>4lyi Chain A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE

Ligand information

InChI=1S/C2H6O3/c3-1-5-2-4/h3-4H,1-2H2

ARZLUCYKIWYSHR-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 12.01 CACTVS 3.385	OCOCO
OpenEye OEToolkits 1.7.6	C(O)OCO

Formula

C2 H6 O3

Name

oxydimethanol

PDB chain

4lyi Chain A Residue 213 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	4lyi 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.
Resolution	1.3 Å
Binding residue (original residue number in PDB)	K160 E163
Binding residue (residue number reindexed from 1)	K119 E122
Annotation score	1

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:4lyi, PDBe:4lyi, PDBj:4lyi
PDBsum	4lyi
PubMed	24272870
UniProt	O60885\|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]