Structure of PDB 4lxl Chain A Binding Site BS01
Receptor Information
>4lxl Chain A (length=329) Species:
9606
(Homo sapiens) [
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QNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQ
TYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYC
TPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTIL
DMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKS
WYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPF
SRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCT
CRKDMVKISMDVFVRILQPERYELWKQGK
Ligand information
>4lxl Chain D (length=8) Species:
9606
(Homo sapiens) [
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ARKSTGGK
Receptor-Ligand Complex Structure
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PDB
4lxl
Crystal structure of JMJD2B complexed with pyridine-2,4-dicarboxylic acid and H3K9me3
Resolution
1.87 Å
Binding residue
(original residue number in PDB)
Y86 N87 D136 E170 G171 Y176 Y178 H241 K242 M243 S289 N291 M313
Binding residue
(residue number reindexed from 1)
Y78 N79 D128 E162 G163 Y168 Y170 H233 K234 M235 S281 N283 M305
Enzymatic activity
Catalytic site (original residue number in PDB)
D136 G171 Y178 H189 E191 H277 S289 N291
Catalytic site (residue number reindexed from 1)
D128 G163 Y170 H181 E183 H269 S281 N283
Enzyme Commision number
1.14.11.66
: [histone H3]-trimethyl-L-lysine(9) demethylase.
External links
PDB
RCSB:4lxl
,
PDBe:4lxl
,
PDBj:4lxl
PDBsum
4lxl
PubMed
UniProt
O94953
|KDM4B_HUMAN Lysine-specific demethylase 4B (Gene Name=KDM4B)
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