Structure of PDB 4lw3 Chain A Binding Site BS01

Receptor Information
>4lw3 Chain A (length=242) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DGASVHKMALLVPFRDRFEELLQFVPHMTAFLKRQGVAHHIFVLNQVDRF
RFNRASLINVGFQFASDVYDYIAMHDVDLLPLNDNLLYEYPSSLGPLHIA
GPKLHPKYHYDNFVGGILLVRREHFKQMNGMSNQYWGWGLENDEFFVRIR
DAGLQVTRPQNIKTGTNDTFSHIHNRYHRKRDTQKCFNQKEMTRKRDHKT
GLDNVKYKILKVHEMLIDQVPVTILNILLDCDVNKTPWCDCS
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4lw3 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4lw3 Crystal Structures of beta-1,4-Galactosyltransferase 7 Enzyme Reveal Conformational Changes and Substrate Binding.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		D147 H241 H243
Binding residue
(residue number reindexed from 1)		D78 H172 H174
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D145 D147 W207 E210 N211 T238 H241 H243
Catalytic site (residue number reindexed from 1) D76 D78 W138 E141 N142 T169 H172 H174
Enzyme Commision number 2.4.1.133: xylosylprotein 4-beta-galactosyltransferase.
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4lw3, PDBe:4lw3, PDBj:4lw3
PDBsum4lw3
PubMed24052259
UniProtQ9VBZ9|B4GT7_DROME Beta-1,4-galactosyltransferase 7 (Gene Name=beta4GalT7)

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