Structure of PDB 4lt5 Chain A Binding Site BS01

Receptor Information
>4lt5 Chain A (length=265) Species: 5762 (Naegleria gruberi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INKKSLLQNLLSKCKTTFQQSFTNANITLKDEKWLKNVRTAYFVCDHDGS
VELAYLPNVLPKELVEEFTEKFESIQTGRKKDTGYSGILDNSMPFNYVTA
DLSQELGQYLSEIVNPQINYYISKLLTCVSSRTINYLVSLNDSYYALNNC
LYPSTAFNSLKPSNDGHRIRKPHKDNLDITPSSLFYFGNFQNTEGYLELT
DKNCKVFVQPGDVLFFKGNEYKHVVANITSGWRIGLVYFAHKGSKTKPYY
EDTQKNSLKIHKETK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4lt5 Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA.
Resolution2.893 Å
Binding residue
(original residue number in PDB)		S148 P150 N232 K318
Binding residue
(residue number reindexed from 1)		S92 P94 N176 K262
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005506 iron ion binding
GO:0010385 double-stranded methylated DNA binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0070579 5-methylcytosine dioxygenase activity

View graph for
Molecular Function
External links
PDB RCSB:4lt5, PDBe:4lt5, PDBj:4lt5
PDBsum4lt5
PubMed24390346
UniProtD2W6T1|TET1_NAEGR Tet-like dioxygenase 1 (Gene Name=TET1)

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