Structure of PDB 4lma Chain A Binding Site BS01

Receptor Information
>4lma Chain A (length=318) Species: 267872 (Microcystis aeruginosa PCC 7806) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRIAHDVTELVGRTPLVQLNRIPQAEGCLGRIVMKLEGMNPAASVKDRIG
THMINSAEKAGLINPETTVLVEPTSGNTGIALAMTAAAKGYRLILTMPET
MSLERRAMLKAYGATLELTPGSQGMKGAILRAQQIVDSIPGAYMLQQFRN
PSNPEIHRLTTAEEIWQDTEGQVDFIVAGVGTGGTITGVAEVIKSRKPSF
QVVAVEPFNSPVISGGNPGPHKIQGIGAGFIPEVLRTDLIDEVITVSDEE
AFQFGRRLAKEEGLLSGISSGANLCAAIQLAQRPENEGKLIVVIQPSFGE
RYLSTLMFQNIEERELTL
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain4lma Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4lma Structural and biochemical analyses of Microcystis aeruginosa O-acetylserine sulfhydrylases reveal a negative feedback regulation of cysteine biosynthesis.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		K46 N77 G181 T182 G183 T185 G225 S269 P296
Binding residue
(residue number reindexed from 1)		K46 N77 G181 T182 G183 T185 G225 S269 P296
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K46 S269
Catalytic site (residue number reindexed from 1) K46 S269
Enzyme Commision number 2.5.1.47: cysteine synthase.
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0019344 cysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4lma, PDBe:4lma, PDBj:4lma
PDBsum4lma
PubMed24275508
UniProtA8YBS4

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