Structure of PDB 4llb Chain A Binding Site BS01
Receptor Information
>4llb Chain A (length=123) Species:
9606
(Homo sapiens) [
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HMLELPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHP
SCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFH
MECCDPPLTRMPKGMWICQICRP
Ligand information
>4llb Chain C (length=15) Species:
9606
(Homo sapiens) [
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ARTKQTARKSTGGKA
Receptor-Ligand Complex Structure
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PDB
4llb
The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
S210 F211 N235 S236 C241 L242 W257 C259 I260 E261 Q271 A275 D276 N277 M278 F280 D282 D285 M300
Binding residue
(residue number reindexed from 1)
S21 F22 N46 S47 C52 L53 W68 C70 I71 E72 Q82 A86 D87 N88 M89 F91 D93 D96 M111
Enzymatic activity
Enzyme Commision number
2.3.1.48
: histone acetyltransferase.
External links
PDB
RCSB:4llb
,
PDBe:4llb
,
PDBj:4llb
PDBsum
4llb
PubMed
24150941
UniProt
Q92794
|KAT6A_HUMAN Histone acetyltransferase KAT6A (Gene Name=KAT6A)
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