Structure of PDB 4lk9 Chain A Binding Site BS01
Receptor Information
>4lk9 Chain A (length=126) Species:
9606
(Homo sapiens) [
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HMLELPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHP
SCLKFSPELTVRVKALRWQCIECKTCSSCRDQGKNADNMLFCDSCDRGFH
MECCDPPLTRMPKGMWICQICRPRKK
Ligand information
>4lk9 Chain B (length=13) Species:
9606
(Homo sapiens) [
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ARTKQTARKSTGG
Receptor-Ligand Complex Structure
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PDB
4lk9
The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.
Resolution
1.6 Å
Binding residue
(original residue number in PDB)
F211 L242 K243 I260 E261 A275 D276 M278 L279 F280 C281 D282 D285 M300 G303
Binding residue
(residue number reindexed from 1)
F22 L53 K54 I71 E72 A86 D87 M89 L90 F91 C92 D93 D96 M111 G114
Enzymatic activity
Enzyme Commision number
2.3.1.48
: histone acetyltransferase.
External links
PDB
RCSB:4lk9
,
PDBe:4lk9
,
PDBj:4lk9
PDBsum
4lk9
PubMed
24150941
UniProt
Q92794
|KAT6A_HUMAN Histone acetyltransferase KAT6A (Gene Name=KAT6A)
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