Structure of PDB 4lim Chain A Binding Site BS01

Receptor Information
>4lim Chain A (length=381) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GANGPSSSDMEYYYKSLYPFKHIFNWLNHSPKPSRDMINREFAMAFRSGA
YKRYNSFNSVQDFKAQIEKANPDRFEIGAIYNKPPREELKALEKELVFDI
DMDDYDAFRTCCSGAQVCSKCWKFISLAMKITNTALREDFGYKDFIWVFS
GRRGAHCWVSDKRARALTDVQRRNVLDYVNVIRDRNTDKRLALKRPYHPH
LARSLEQLKPFFVSIMLEEQNPWEDDQHAIQTLLPALYDKQLIDSLKKYW
LDNPRRSSKEKWNDIDQIATSLFKGPKQDSHIIKLRECKEDLVLMTLYPK
LDVEVTKQTIHLLKAPFCIHPATGNVCVPIDESFAPEKAPKLIDLQTEME
KNNDVSLTALQPFINQFQAYVSSLLKNELGS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4lim Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4lim Insights into Eukaryotic Primer Synthesis from Structures of the p48 Subunit of Human DNA Primase.
Resolution1.63 Å
Binding residue
(original residue number in PDB)		C123 C124 C130 C133
Binding residue
(residue number reindexed from 1)		C111 C112 C118 C121
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.-
Gene Ontology
Molecular Function
GO:0003697 single-stranded DNA binding
GO:0003896 DNA primase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006269 DNA replication, synthesis of primer
GO:0006270 DNA replication initiation
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005658 alpha DNA polymerase:primase complex
GO:0043596 nuclear replication fork
GO:1990077 primosome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4lim, PDBe:4lim, PDBj:4lim
PDBsum4lim
PubMed24239947
UniProtP10363|PRI1_YEAST DNA primase small subunit (Gene Name=PRI1)

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