Structure of PDB 4lc9 Chain A Binding Site BS01

Receptor Information
>4lc9 Chain A (length=567) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVKLLGQC
DAEIFQEEGQIVPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSG
GGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREQTEDSA
LHGIEELKKVAAGKKRVVVIGISVGLSAPFVAGQMDYCMDNTAVFLPVLV
GFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSG
SSRMKGGGATKILLETLLLAAHKTVVSSQRCLLEILRTFERAHQVTYSQS
SKIATLMKQVGISLEKKGRVHLVGWQTLGIIAIMDGVECIHTFGADFQDI
RGFLIGDTSILPSLTETDTVVFIFTLDDNLTEVQALAERVRCQNIQALVH
STVGQSLPAPLKKLFPSLISITWPLLFFDYEGTYVQKFQRELSTKWVLNT
VSTGAHVLLGKILQNHMLDLRIANSKLFWRALAMLQRFSGQSKARCIESL
LQAIHFPQPLSDDVRAAPISCHVQVAHEKEKVIPTALLSLLLRCSISEAK
ARLSAASSVCEVVRSAL
Ligand information
Ligand IDF6P
InChIInChI=1S/C6H13O9P/c7-2-6(10)5(9)4(8)3(15-6)1-14-16(11,12)13/h3-5,7-10H,1-2H2,(H2,11,12,13)/t3-,4-,5+,6-/m1/s1
InChIKeyBGWGXPAPYGQALX-ARQDHWQXSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=P(O)(O)OCC1OC(O)(CO)C(O)C1O
OpenEye OEToolkits 1.5.0C(C1C(C(C(O1)(CO)O)O)O)OP(=O)(O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@](O1)(CO)O)O)O)OP(=O)(O)O
CACTVS 3.341OC[C]1(O)O[CH](CO[P](O)(O)=O)[CH](O)[CH]1O
CACTVS 3.341OC[C@@]1(O)O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@@H]1O
FormulaC6 H13 O9 P
Name6-O-phosphono-beta-D-fructofuranose;
FRUCTOSE-6-PHOSPHATE;
6-O-phosphono-beta-D-fructose;
6-O-phosphono-D-fructose;
6-O-phosphono-fructose
ChEMBLCHEMBL604196
DrugBank
ZINCZINC000004096690
PDB chain4lc9 Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4lc9 Structural basis for regulation of human glucokinase by glucokinase regulatory protein.
Resolution3.4 Å
Binding residue
(original residue number in PDB)		G108 T109 E150 S179 V180 G181 S258 K514
Binding residue
(residue number reindexed from 1)		G102 T103 E144 S173 V174 G175 S252 K476
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0019210 kinase inhibitor activity
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019904 protein domain specific binding
GO:0030246 carbohydrate binding
GO:0070095 fructose-6-phosphate binding
GO:0097367 carbohydrate derivative binding
GO:0141089 glucose sensor activity
Biological Process
GO:0001678 intracellular glucose homeostasis
GO:0006006 glucose metabolic process
GO:0006606 protein import into nucleus
GO:0009749 response to glucose
GO:0009750 response to fructose
GO:0033133 positive regulation of glucokinase activity
GO:0034504 protein localization to nucleus
GO:0042593 glucose homeostasis
GO:0046415 urate metabolic process
GO:0070328 triglyceride homeostasis
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4lc9, PDBe:4lc9, PDBj:4lc9
PDBsum4lc9
PubMed23957911
UniProtQ07071|GCKR_RAT Glucokinase regulatory protein (Gene Name=Gckr)

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