Structure of PDB 4lam Chain A Binding Site BS01

Receptor Information

>4lam Chain A (length=365) Species: 983644 (Cordyceps militaris CM01)

TPVVVDIHTHMYPPSYIAMLEKRQTIPLVRTFPQADEPRLILLSSELAAL
DAALADPAAKLPGRPLSTHFASLAQKMHFMDTNGIRVSVISLANPWFDFL
APDEAPGIADAVNAEFSDMCAQHVGRLFFFAALPLSAPVDAVKASIERVK
NLKYCRGIILGTSGLGKGLDDPHLLPVFEAVADAKLLVFLHPHYGLPNEV
YGPRSEEYGHVLPLALGFPMETTIAVARMYMAGVFDHVRNLQMLLAHSGG
TLPFLAGRIESCIVHDGHLVKTGKVPKDRRTIWTVLKEQIYLDAVIYSEV
GLQAAIASSGADRLMFGTNHPFFPPIWDSSRLNAQAVIKAVGEGSSDAAA
VMGLNAVRVLSLKAE

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 4lam Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4lam Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): H12 H14 H195 N323
• Binding residue (residue number reindexed from 1): H8 H10 H191 N319
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0016787 hydrolase activity
• GO:0016831 carboxy-lyase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0019748 secondary metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4lam, PDBe:4lam, PDBj:4lam
• PDBsum: 4lam
• PubMed: 23917530
• UniProt: G3J531