Structure of PDB 4lak Chain A Binding Site BS01

Receptor Information

>4lak Chain A (length=336) Species: 983644 (Cordyceps militaris CM01) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PVVVDIHTHMYPPSYIAMLEKRQTIPLLPGRPLSTHFASLAQKMHFMDTN
GIRVSVISLANPWFDFLAPDEAPGIADAVNAEFSDMCAQHVGRLFFFAAL
PLSAPVDAVKASIERVKNLKYCRGIILGTSGLGKGLDDPHLLPVFEAVAD
AKLLVFLHPHYGLPNEVYGPRSEEYGHVLPLALGFPMETTIAVARMYMAG
VFDHVRNLQMLLAHSGGTLPFLAGRIESCIVHDGHLVKTGKVPKDRRTIW
TVLKEQIYLDAVIYSEVGLQAAIASSGADRLMFGTNHPFFPPIEEDVQGP
WDSSRLNAQAVIKAVGEGSSDAAAVMGLNAVRVLSL

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

4lak Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4lak Crystal structures of isoorotate decarboxylases reveal a novel catalytic mechanism of 5-carboxyl-uracil decarboxylation and shed light on the search for DNA decarboxylase.
Resolution	2.41 Å
Binding residue (original residue number in PDB)	H12 H14 H195 N323
Binding residue (residue number reindexed from 1)	H7 H9 H158 N286
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0016787	hydrolase activity
GO:0016831	carboxy-lyase activity
GO:0046872	metal ion binding

	Biological Process
GO:0019748	secondary metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4lak, PDBe:4lak, PDBj:4lak
PDBsum	4lak
PubMed	23917530
UniProt	G3J531

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