Structure of PDB 4l0y Chain A Binding Site BS01

Receptor Information
>4l0y Chain A (length=128) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPD
GTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLT
ITVFTNPPQVATYHRAIKITVDGPREPR
Ligand information
Receptor-Ligand Complex Structure
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PDB4l0y Structural basis of Ets1 activation by Runx1.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		R142 K167 T169 V170 D171
Binding residue
(residue number reindexed from 1)		R93 K118 T120 V121 D122
Binding affinityPDBbind-CN: Kd=3.1nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005524 ATP binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4l0y, PDBe:4l0y, PDBj:4l0y
PDBsum4l0y
PubMed24646888
UniProtQ03347|RUNX1_MOUSE Runt-related transcription factor 1 (Gene Name=Runx1)

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