Structure of PDB 4kxt Chain A Binding Site BS01

Receptor Information
>4kxt Chain A (length=806) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNRE
VVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDKVSIKWLAI
VSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEG
YYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEV
LDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRR
PASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHT
YLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNAS
YNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDM
RGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQG
QPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGD
TLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVF
QQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQE
IIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAI
RDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVD
TNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLC
HTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKRDPQALAKAVQVHQDTL
RTMYFA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4kxt Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity.
Resolution2.294 Å
Binding residue
(original residue number in PDB)		A219 H269 F292 Q295 Y309 K313 Y314 H334 T335 Y336 T359 I363 T366 G522 K523 T524 Y527 K531 Q543 C544 Q546 N549 T557 N560 L561 K564 K568 R712 H751 I754 Q755 S758 R759 Y788 R790 C791 S796 Y802
Binding residue
(residue number reindexed from 1)		A184 H234 F257 Q260 Y274 K278 Y279 H299 T300 Y301 T324 I328 T331 G487 K488 T489 Y492 K496 Q508 C509 Q511 N514 T522 N525 L526 K529 K533 R677 H716 I719 Q720 S723 R724 Y753 R755 C756 S761 Y767
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000993 RNA polymerase II complex binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0035198 miRNA binding
GO:0061980 regulatory RNA binding
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006417 regulation of translation
GO:0010501 RNA secondary structure unwinding
GO:0016525 negative regulation of angiogenesis
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0031054 pre-miRNA processing
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0035196 miRNA processing
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
GO:0043488 regulation of mRNA stability
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070922 RISC complex assembly
GO:0090625 siRNA-mediated gene silencing by mRNA destabilization
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016442 RISC complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043232 intracellular non-membrane-bounded organelle
GO:0070578 RISC-loading complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4kxt, PDBe:4kxt, PDBj:4kxt
PDBsum4kxt
PubMed23809764
UniProtQ9UL18|AGO1_HUMAN Protein argonaute-1 (Gene Name=AGO1)

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