Structure of PDB 4kxq Chain A Binding Site BS01

Receptor Information
>4kxq Chain A (length=279) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYA
RLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIA
LSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCE
AVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKD
EVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGD
CDVIINELCHRLGGEYAKLCCNPVKLSEI
Ligand information
>4kxq Chain B (length=26) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GPHMGSQYLFLPPNRYIFHGAEVYSD
Receptor-Ligand Complex Structure
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PDB4kxq Structural and Functional Analysis of Human SIRT1.
Resolution1.849 Å
Binding residue
(original residue number in PDB)		K236 N241 T242 I243 R276 R466 P468 D475 E477 L479 G480 D481 I485
Binding residue
(residue number reindexed from 1)		K5 N10 T11 I12 R45 R235 P237 D244 E246 L248 G249 D250 I254
Enzymatic activity
Catalytic site (original residue number in PDB) P271 D272 F273 R274 N346 D348 H363
Catalytic site (residue number reindexed from 1) P40 D41 F42 R43 N115 D117 H132
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:4kxq, PDBe:4kxq, PDBj:4kxq
PDBsum4kxq
PubMed24120939
UniProtQ96EB6|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

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