Structure of PDB 4kv4 Chain A Binding Site BS01
Receptor Information
>4kv4 Chain A (length=111) Species:
9606
(Homo sapiens) [
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AGSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPM
DMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQD
VFEMRFAKMPD
Ligand information
>4kv4 Chain B (length=5) Species:
9606
(Homo sapiens) [
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TFKSI
Receptor-Ligand Complex Structure
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PDB
4kv4
Brd4 maintains constitutively active NF-kappa B in cancer cells by binding to acetylated RelA.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
W29 V35 N88 H92
Binding residue
(residue number reindexed from 1)
W26 V32 N85 H89
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:4kv4
,
PDBe:4kv4
,
PDBj:4kv4
PDBsum
4kv4
PubMed
23686307
UniProt
O60885
|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)
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