Structure of PDB 4ktx Chain A Binding Site BS01

Receptor Information
>4ktx Chain A (length=428) Species: 441771 (Clostridium botulinum A str. Hall) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPE
RDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFER
IYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNSINVIQPDGSYRSE
ELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFE
ESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNT
NAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTL
NKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTE
IYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNL
AANFNGQNTEINNMNFTKLKNFTGLFEF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ktx Covalent modification of the active site cysteine stresses Clostridium botulinum neurotoxin A
Resolution2.59 Å
Binding residue
(original residue number in PDB)		Q162 F163 E164 C165 F194 H223 E224 H227 E262 R363 Y366 D370
Binding residue
(residue number reindexed from 1)		Q165 F166 E167 C168 F197 H226 E227 H230 E265 R366 Y369 D373
Enzymatic activity
Catalytic site (original residue number in PDB) H223 E224 H227 E262 R363
Catalytic site (residue number reindexed from 1) H226 E227 H230 E265 R366
Enzyme Commision number 3.4.24.69: bontoxilysin.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4ktx, PDBe:4ktx, PDBj:4ktx
PDBsum4ktx
PubMed
UniProtP0DPI1|BXA1_CLOBH Botulinum neurotoxin type A (Gene Name=botA)

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