Structure of PDB 4krf Chain A Binding Site BS01

Receptor Information
>4krf Chain A (length=817) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPR
RVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVT
IPKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLAS
MRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSA
TAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTH
CGKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYP
HLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAP
DRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGR
NRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQ
LRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILP
GKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGG
INNILVPHQRSAVFQQPVIFLGADVTHPPAKKPSITAVVGSMDAHPSRYC
ATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQL
PQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGK
SGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTA
DELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKRDPQAL
AKAVQVHQDTLRTMYFA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4krf The making of a slicer: activation of human argonaute-1.
Resolution2.101 Å
Binding residue
(original residue number in PDB)		S218 A219 H269 R275 F292 Y309 Y314 H334 T335 Y336 M362 I363 T366 R373 L520 G522 T524 Y527 K531 Q543 C544 Q546 N549 Q556 T557 N560 K564 K568 R633 R708 R712 H751 I754 Q755 T757 S758 R759 Y788 R790 C791 S796 Y802
Binding residue
(residue number reindexed from 1)		S199 A200 H250 R254 F271 Y288 Y293 H313 T314 Y315 M341 I342 T345 R352 L499 G501 T503 Y506 K510 Q522 C523 Q525 N528 Q535 T536 N539 K543 K547 R609 R684 R688 H727 I730 Q731 T733 S734 R735 Y764 R766 C767 S772 Y778
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000993 RNA polymerase II complex binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0035198 miRNA binding
GO:0061980 regulatory RNA binding
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006417 regulation of translation
GO:0010501 RNA secondary structure unwinding
GO:0016525 negative regulation of angiogenesis
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0031054 pre-miRNA processing
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0035196 miRNA processing
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
GO:0043488 regulation of mRNA stability
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070922 RISC complex assembly
GO:0090625 siRNA-mediated gene silencing by mRNA destabilization
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016442 RISC complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043232 intracellular non-membrane-bounded organelle
GO:0070578 RISC-loading complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4krf, PDBe:4krf, PDBj:4krf
PDBsum4krf
PubMed23746446
UniProtQ9UL18|AGO1_HUMAN Protein argonaute-1 (Gene Name=AGO1)

[Back to BioLiP]