Structure of PDB 4kre Chain A Binding Site BS01

Receptor Information
>4kre Chain A (length=799) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRR
VNREVVEYMVQHFKIFGDRKPVYDGKKNIYTVTALPIGERVDFEVTRIFK
VSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGR
SFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQP
VIEFMCEVLDIRQPKPLTDSQRVRFTKEIKGLKVEVTHCGKRKYRVCNVT
RRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGHTYL
PLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYN
LDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRNRAIATPNQGVWDMRG
KQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQP
CFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTL
LGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQ
PVIFLGADVTHPPKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLS
YMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIK
LEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHP
FEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRC
TRSVSIPAPAYYARLVAFRARYHLVDRDPQALAKAVQVHQDTLRTMYFA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4kre The making of a slicer: activation of human argonaute-1.
Resolution1.754 Å
Binding residue
(original residue number in PDB)		S218 A219 H269 R275 F292 Y309 Y314 H334 T335 Y336 R349 I363 T366 Y527 K531 Q543 C544 V545 Q546 N549 T557 N560 L561 K564 K568 R708 R712 H751 I754 Q755 S758 R759 Y788 R790 C791 R793 S796 Y802 Y813
Binding residue
(residue number reindexed from 1)		S191 A192 H238 R242 F259 Y276 Y281 H297 T298 Y299 R312 I326 T329 Y490 K494 Q506 C507 V508 Q509 N512 T520 N523 L524 K527 K531 R667 R671 H710 I713 Q714 S717 R718 Y747 R749 C750 R752 S755 Y761 Y772
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000993 RNA polymerase II complex binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0035198 miRNA binding
GO:0061980 regulatory RNA binding
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006417 regulation of translation
GO:0010501 RNA secondary structure unwinding
GO:0016525 negative regulation of angiogenesis
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0031054 pre-miRNA processing
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0035196 miRNA processing
GO:0035278 miRNA-mediated gene silencing by inhibition of translation
GO:0035279 miRNA-mediated gene silencing by mRNA destabilization
GO:0043488 regulation of mRNA stability
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070922 RISC complex assembly
GO:0090625 siRNA-mediated gene silencing by mRNA destabilization
Cellular Component
GO:0000932 P-body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016442 RISC complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043232 intracellular non-membrane-bounded organelle
GO:0070578 RISC-loading complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4kre, PDBe:4kre, PDBj:4kre
PDBsum4kre
PubMed23746446
UniProtQ9UL18|AGO1_HUMAN Protein argonaute-1 (Gene Name=AGO1)

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