Structure of PDB 4kr7 Chain A Binding Site BS01

Receptor Information
>4kr7 Chain A (length=386) Species: 243274 (Thermotoga maritima MSB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELRVYIVRYSEIGLKGKNRKDFEEALRRNIERVTGMKVKRQWGRFLIPID
ENVTLDDKLKKIFGIQNFSKGFLVSHDFEEVKKYSLIAVKEKLEKGNYRT
FKVQAKKAYKEYKKGVYEINSELGALILKNFKELSVDVRNPDFVLGVEVR
PEGVLIFTDRVECYGGLPVGTGGKAVLLLSGGIDSPVAGWYALKRGVLIE
SVTFVSPPFTSEGAVEKVRDILRVLREFSGGHPLRLHIVNLTKLQLEVKK
RVPDKYSLIMYRRSMFRIAEKIAEETGAVAFYTGENIGQVASQTLENLWS
IESVTTRPVIRPLSGFDKTEIVEKAKEIGTYEISIKPYQDSCVFFAPKNP
ATRSHPSILEKLEQQVPDLPVLEEEAFTSRKVEVIE
Ligand information
>4kr7 Chain M (length=39) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcccggauaguguccuugggaaaccaaguccgggcacca
<<<<<<<<.......<<<<....>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB4kr7 Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification.
Resolution3.421 Å
Binding residue
(original residue number in PDB)		I14 K17 G18 R21 K22 R42 K104 V105 K108 Y111 V118 Y119 N122 S123 G126 A127 V140 R141 R152
Binding residue
(residue number reindexed from 1)		I12 K15 G16 R19 K20 R40 K102 V103 K106 Y109 V116 Y117 N120 S121 G124 A125 V138 R139 R150
Enzymatic activity
Enzyme Commision number 2.8.1.4: tRNA uracil 4-sulfurtransferase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0004810 CCA tRNA nucleotidyltransferase activity
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0016783 sulfurtransferase activity
GO:0140741 tRNA-uracil-4 sulfurtransferase activity
Biological Process
GO:0002937 tRNA 4-thiouridine biosynthesis
GO:0009228 thiamine biosynthetic process
GO:0009229 thiamine diphosphate biosynthetic process
GO:0034227 tRNA thio-modification
GO:0052837 thiazole biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:4kr7, PDBe:4kr7, PDBj:4kr7
PDBsum4kr7
PubMed24705700
UniProtQ9X220|THII_THEMA Probable tRNA sulfurtransferase (Gene Name=thiI)

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