Structure of PDB 4kjd Chain A Binding Site BS01
Receptor Information
>4kjd Chain A (length=408) Species:
10116
(Rattus norvegicus) [
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VEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATR
ILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGV
KANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQH
ASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGG
RKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQL
MQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNP
QGFYLFVEGGRIDQGHTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITA
DHSHVTLRHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTD
CGLAPPAD
Ligand information
Ligand ID
MG
InChI
InChI=1S/Mg/q+2
InChIKey
JLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mg+2]
CACTVS 3.341
[Mg++]
Formula
Mg
Name
MAGNESIUM ION
ChEMBL
DrugBank
DB01378
ZINC
PDB chain
4kjd Chain A Residue 501 [
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Receptor-Ligand Complex Structure
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PDB
4kjd
Crystal structure of rat intestinal alkaline phosphatase - Role of crown domain in mammalian alkaline phosphatases.
Resolution
2.21 Å
Binding residue
(original residue number in PDB)
S155 E311
Binding residue
(residue number reindexed from 1)
S152 E308
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
D42 S92 H153 S155 R166 E311 D316 Q317 D357 H358 H432
Catalytic site (residue number reindexed from 1)
D39 S89 H150 S152 R163 E308 D313 Q314 D351 H352 H359
Enzyme Commision number
3.1.3.1
: alkaline phosphatase.
Gene Ontology
Molecular Function
GO:0000287
magnesium ion binding
GO:0002020
protease binding
GO:0004035
alkaline phosphatase activity
GO:0005515
protein binding
GO:0008270
zinc ion binding
GO:0016787
hydrolase activity
GO:0016791
phosphatase activity
GO:0042803
protein homodimerization activity
GO:0046872
metal ion binding
Biological Process
GO:0016311
dephosphorylation
GO:0071773
cellular response to BMP stimulus
Cellular Component
GO:0005886
plasma membrane
GO:0009897
external side of plasma membrane
GO:0098552
side of membrane
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:4kjd
,
PDBe:4kjd
,
PDBj:4kjd
PDBsum
4kjd
PubMed
24076154
UniProt
P15693
|PPBI1_RAT Intestinal-type alkaline phosphatase 1 (Gene Name=Alpi)
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